無溶劑體系中酪氨酸酶催化氧化-邁克爾加成反應(yīng)的新應(yīng)用.pdf

1、767014分類號(hào)，密衄城號(hào)攙恭嚳碩士學(xué)位淪文盎墨型整壅!壁熟墮墮焦絲墨堡二塹塞墨壟墮墾生塑塹壘旦學(xué)位中詩兒：導(dǎo)師姓名廈職稱鐘誠馬林教授專業(yè)名稱有機(jī)化掌；o。置年女月☆EAbstractAbstractAsthedevelopmentofthebiologicaltechnology，enzymaticcatalyticreactionshavebeenextensivelystudiedandhavebeenappliedinmany

2、aspectsinscientificresearchandindustry，suchasasymmetrysynthesis，opticalactivecompoundsandsynthesisofnaturalproductsThiskindofreactionsplaysaveryimportantroleinpharmacy，foodindustry，textileindustryandotherlightindustriesI

3、tiswellknownthattyrosinaseisthekeyenzymeofmelaninbiosynthesis，whichcatalyzestwodistinctreactionsinvolvingmolecularoxygen：thehydroxylationofmonophenolstoodiphenolsandtheoxidationofbothtoo—quinoneswhichareetectrophilicandk

4、nownwithundergoingavarietyofnonenzymaticreactionssuchasOxidationMichaeladditionreactionwithaminoorthiolgroupsBasedonthetyrosinasecatalyticreactionandthefollowingOxidation—Michaeladditionreaction，inthisarticle，thedevelopm

5、entoftyrosinasecatalyticreactioninrecentyearsisintroduced，containingmainlytwosectionsasfollow：1Withthepsubstitutedphenolsasthesubstrates，anewseriesofphenoxazonederivativesweresynthesizedthroughthesolvent—freetyrosinaseca

6、talyticreactionThepossiblemechanismwasillustratedandtheinfluencesofdifferentratiobetweenthetwosubstratesanddifferentreactionsystemswerestudied2BasedonthetyrosinasecatalyticreactionandOxidationMichaeladditionreaction，newm