γ-內(nèi)酯的酶法動(dòng)力學(xué)拆分以及α-支鏈醛的不對(duì)稱(chēng)氫轉(zhuǎn)移動(dòng)態(tài)動(dòng)力學(xué)拆分.pdf

1、蘇州大學(xué)碩士學(xué)位論文γ內(nèi)酯的酶法動(dòng)力學(xué)拆分以及α支鏈醛的不對(duì)稱(chēng)氫轉(zhuǎn)移動(dòng)態(tài)動(dòng)力學(xué)拆分姓名：吳國(guó)峰申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：有機(jī)化學(xué)指導(dǎo)教師：張雅文20080501英文摘要EnzymaticResolutionof嚴(yán)LactonesandDynamicKineticResolutionof弘BranchedAldehydesbyUsingAsymmetricTransferHydrogenationReactionABSTRACT1Prepa

2、rationofOpticallyActiveLactones1，婦EnzymaticResolutionEnz)吼aticresolutionofracemicg鋤auIldecalactonea芏1dg鋤adec猷actonehaSbeene量FectivelystudiedbymeallsofthelipaSeselectiVelycatalyzedhydrolysisreactionTheinfluerlcefactorsSuc

3、h嬲tempera：ture，pHValueaIldtheamo吼tsoft11elipaSe、Ⅳere0pti商sedEmploymentoftheaq【ueousso】utionofcalciumclllo矗decontaillinggumaufabicasmereaCtionmedi眥，iII]【proVedt11ePPoft11eresolutionproductTheg鋤ahydroxyacidfonllediIltheres

4、olutionwaSrecovered，racemized，lactoIlizeda11drecycledinthenextr眥1，訛chi瑚【proVedtheyieldoftheopticallyactiVelaCtone2DynamiclQneticResolutionof2AII呵l—肛KetoAldehydesbyUsingAsymmetricrIransferHydrogenationAsy刪[netric恤s矗玎hydro

5、genationofaseriesof2一alkyl肛ketoaldehydes1a一1pusingHC00H：Et3N=5：2asmehydrogenso眥eand㈣一TsDPENbaLsedRu(II)catalysts1，砌dyn疵c虹neticresolutionproccedstosyn_t11esizecorresponding2猷kyl盧ket0p血1啊alcohols2a2pwithgoodyields鋤dmoderat

6、eeeValuesnlesereaCtionso毹ranaltemativefort：hepr印aIationofaldoltypeimemediatesbya110naldolpathway3DynamicKineticResolutionof西7rosylAldehydesbyUsingAsymmetricTtansferHydrogenationEnatioselectivereductionof仿tosylaldehydes10