6-甲基脲嘧啶及其N-,1--取代衍生物的合成研究.pdf

1、西北大學碩士學位論文6甲基脲嘧啶及其N取代衍生物的合成研究姓名：齊曉麗申請學位級別：碩士專業(yè)：有機化學指導教師：劉毅鋒20090610西北大學碩士論文英文摘要Abstract6MethyluracileandderivativesareakindofversatileheterocycliccompoundsUracileswhichisthebasiccomponentsofmanynaturalproductsandhasthego

2、odbiologicalactivitymaybeusedintheantitumoranti—HIVthesterilizationaswellastheanti—filterablepathogenandSOonItisalsoakindofimportantsynthesisintermediateofmedicineandpesticideWereportaconvenientmethodforsynthesisof6methy

3、luracileandsevenⅣlsubstituted6methyluracilecompoundsbytwostepsfromethylacetoacetateandethylcarbamate，andthesynthesisofⅣI一[2(aryloxy)ethoxy]6methyluracile，whichhasthegoodanti—HIVactivitywascarriedoutbyaprocessconsisitingo

4、fsixstepsThestructuresofthecompoundswereconfirmedbyIR，MSand1HNMR。Usingzincacetateascatalyst，acetoaceticesterwhichtumsintotheenolforminthenonpolarsolvent，reactedwithethylcarbamateat1400Cfor6htogive6methyl2，3一dihydrogen一1，

5、3一oxazine2，4一dioneinyieldof823％OxazinedionereactedwithamineorNsubstitutedamineat150—160。Cfor2htogiveⅣ1一substituted一6一methyluracilederivativesandtheyieldis75％一90％Six2(aryloxy)ethanolweresynthesizedbythereactionofphenoland

6、chloroethan01Intheprocess，wehasnotusedthephasetransfercatalystaccordingtotheliteraturereport，butusedthesuitablesolventasdehydratingagentafterthefirstcondensation，improvingtheyieldto92％1[2一(Chloromethoxy)ethoxy]一4一methylb

7、enzeneweresynthesizedbychloro—methylationof2一(aryloxy)ethanolwithparaformaldehydeanddryhydrogenchloride，andundertheoptimizingreactioncondition，theyieldofthereactionis903％AccordingtotheclassicsGabrielreaction，UsingtheCTAC