1,5-苯并硫氮雜卓-α-氨基-β-內酰胺衍生物的合成及不對稱合成的研究.pdf

1、河北師范大學碩士學位論文15苯并硫氮雜卓α氨基β內酰胺衍生物的合成及不對稱合成的研究姓名：李旭申請學位級別：碩士專業(yè)：有機化學指導教師：李媛2000.5.1河北師范火學理學碩‘學位論文AbstractBenzothiazepineisakindofcompoundwhichhasimportanlbiologicalactivitiesTheirsynthesis，structuresandpharmacologicalactiviti

2、eshaveattractedwideattentionCycloadditionreactionsattheiractiveimine(C=N)doublebondhavearousedchemims’interest，becausetheincorporationofnewcyclicsystemmayresultinneweffectonstereochemistryandbiologicalactivitiesofbenzoth

3、iazepinesOurgrouphavebeendoingextensivestudiesontheir[22】cycloadditionreaction，Aseriesofnovelheterocycliccompoundshavebeensynthesized，andtheirconformmionshavebeenanalyzed，ThereactionmechanismshavebeenstudiedThecurrentpap

4、erisapartofthissystematicinvestigation，Themainresearchaspectsareasfollows：(1)Thestudyonsynthesisof1，5一benzothiazepionaamino13一lactamInourpreviouswork，wehaveincorporatedthe3lactamringinto15。benzothiazepinebyreactionof15一b

5、enzothiazepinewithsomeacylchloridesandsynthesizedaseriesofnew13lactamderivativesof1，5benzothiazepineBaseonthese，consideringthatsomekindsofp—lactamantibiticeshaveaminooramidegrouponⅨpositionof13一lactamringInordertofindnew

6、p。lactamderivativesof15benzothiazepine，whichshowsignificantactivityandfurtherstudyinfluenceofsubstitutionatapositionof131actamringonconfigurationof13lactammoietyWedesignedandpreparedsix’Ⅱ。amino一6一lactamderivativesof15一be