乳腺癌Survivin、BCRP基因表達與新輔助化療TE方案的療效相關性研究.pdf

1、新疆醫(yī)科大學碩士學位論文乳腺癌Survivin、BCRP基因表達與新輔助化療TE方案的療效相關性研究姓名：李妍申請學位級別：碩士專業(yè)：腫瘤學指導教師：楊順娥201104新疆醫(yī)科大學碩士學位論文新疆醫(yī)科大學碩士學位論文２２CrelationstudyofExpressionofSurvivinBCRPgenewiththerapeuticresponseofNeoadjuvantChemotherapyofTEinpatientswith

2、BreastCancerPostgraduate：LiYanSupervis：YangShun’eAbstractObjective：TostudytheexpressionchangesofsurvivinmRNABCRPmRNAinbreastcancerafterTEregimen(DocetaxelEpirubinciin)neoadjuvantchemotherapyanalyzetherelationshipbetweene

3、xpressionchangesefficiencyofneoadjuvantchemotherapysearchfbiologicalmarkerstopredicttheeffectofthisneoadjuvantchemotherapy.Methods：TheexpressionofsurvivinmRNABCRPmRAweredetectedbySemiquantitativereversetranionpolymerasec

4、hainreaction(RTPCR)from44breastcancerpatientsbefeafterneoadjuvantchemotherapyofTEregimen(DocetaxelEpirubinciin).TherelationshipbetweensurvivinmRNABCRPmRNAexpressionchemotherapyresponsewereanalyzed.Results：1.Theoverallres

5、ponseratetoneoadjuvantchemotherapywas70.5%.including9.1%(444)withcompleteresponse61.4%(2744)withpartialresponse.Stablediseaseprogressionofdiseasewere25%(1144)4.5%(244)respectively.2.Theexpressionofsurvivinafterneoadjuvan

6、tchemotherapywas36.4%whichwassignificantlylowerthan59.1%befeneoadjuvantchemotherapy(P0.05).TheefficientofthepositiveexpressionoftwogroupsofsurvivinmRNABCRPmRNAwerelowerthanthenegativegroups(P0.05).Conclusions:TEregimenis

7、anefficienciveneoadjuvantchemotherapyinbreastcancer.TheexpressionofsurvivinmRNABCRPmRNAinfluencedtheeffectiveofchemotherapyitmadethepatientsgotpoefficacyofchemotherapy.SurvivincombineswithBCRPcouldbedetectedtoguidechemot