PTEN和p33-ING1的表達(dá)與食管鱗癌發(fā)生、發(fā)展浸潤(rùn)轉(zhuǎn)移關(guān)系的研究.pdf

1、內(nèi)蒙古醫(yī)學(xué)院碩士學(xué)位論文PTEN和p33ING1的表達(dá)與食管鱗癌發(fā)生、發(fā)展浸潤(rùn)轉(zhuǎn)移關(guān)系的研究姓名：李慧娥申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：內(nèi)科學(xué)指導(dǎo)教師：冷雪芹20090501TheresearchontherelationshipbetweentheexpressionofPTENandp33／INGIandtheoccurrence，development，invasionandtransferenceofesophagusscalecanc

2、erAbstractcancerarecommonmalignanttumorsinChina，稍tllmostofthesanletumor，theincidenceofesophagealcancer，development，andinvasionandmetastasisisamulti—factor，multi—stageandmulti—genechangesinacoherentprocessgealinvasionandd

3、istantmetastasisinpatientswithEsophacancer蹴affectedsurvivaltimeandqualityoflifeoneofthemainfactors，butalsothemainreasonfordeathTherefore，tllemechanismofinvasionandmetastasisofesophagealcancerhasbecomeastudyofoneofthehots

4、potsStudyofthesegenesinvolvedintumoroccurrenceanddevelopmentofmolecularevents，theearlydiagnosisoftumor腳嗆alsoawholenewfield，butalsopromisingtoexploreDeeper，broaderexplorationofmolecularinteractionandgeneexpressionregulati

5、onmechanism，alsohelpstoclarifythemechanismoftumorObjectiveWeadiscussedtherelationshipbetweentheexpressionofPTENandp33／INGl，theinvasionandtransferenceofthecancer，andwealsotalkedaboutwhethertlleyhavethecommoneffortinthewho

6、leprocessandwhatitsinternalrelationshipamongthemThuswecoulddetermineforearlierdetectionoftheoccurrence，development，invasionandtransference，andgiveitssolutionsItprovidestheoreticalbasisforfurtherdiscussiononthemechanismof

7、thecancerswholeprocessandtreatmentMethodWiththehelpofimmunohistochemistrySPmethod，detecttheexpressionofPTENandp33／INGlin58sampleesophagealsquamouscellcarcinoma，adjacentatypicalhyperplasiaandnormalesophagealmucosarespecti

8、v由Analyzethedifferencesofthetwoproteinshowninthedifferentlevelofdifferentiation，infdtrationofesophagusscalecancerandwhetherthereisacancertissuesonmetastasisoflymphnodeResultsPTENandP33／INGlshowedgraduallowexpressioninthe