遺傳因素和農(nóng)藥接觸對原發(fā)性痛經(jīng)影響的研究.pdf

1、安徽醫(yī)科大學碩士學位論文遺傳因素和農(nóng)藥接觸對原發(fā)性痛經(jīng)影響的研究姓名：張軍申請學位級別：碩士專業(yè)：流行病與衛(wèi)生統(tǒng)計學指導教師：徐希平臧桐華2002.5.1安徽醫(yī)科大學碩士學位論文TheStudyoftheGeneticFactorandpesticideexposureonPrimaryDysmenorrheaAbstractObjective：Inordertoinvestigatethegeneticfactorandpestici

2、deexposureonprimarydysmenorrheaintwinsinruralareaMethods：WecarriedoutalargescalecrosssectionalstudyinAnhuiProvinceAccordingtothestandardquestionaire，informationsonprimarydysmenofrheaandiaesticideexposure，sociodemographic

3、andrelatedenvironmentalandoccupationalvariableswereobtainedbytrainedinterviewers’roidentifyzygosityoftwins，tenhighlypolymrophicgeneticmarkerswereselectedandscannedonABl377machineAllthedataweredoubleentriedandcheckedbyEPI

4、INFOandanalyzedbySASResults：IntheStudyOne，wetotallycollectedeligible1311pairsoftwins，908Monozygotictwins(MZ)and403Dizygotictwins(DZ)Logisticregressionwasappliedtoanalyzetheriskofthesamedegreeprimarydysmenorrheaintwinswit

5、handwithoutadjustmentforconfoundingfactorsTheresultsshowedthatORvaluewassignificantinMZandORvaluewasalsosignificantexceptforsevereprimarydysmenorrheainDZInadditon，ORvalueofMZwashigherthanthatofDZIntheStudyTwo，wecollected

6、3286eligiblefemaleLogisticregressionwasappliedtoanalyzepesticideexposureonprimarydysmenorrheawithandwiflmutadjustmentforconfoundingfactorsTheresultrevealedthatpesticide(P001)OR2I235(95％CI：I054一I446)wassingnificantlyassoc

7、iatedwithprimar)rdysmenorrheaMeanwhile，ageandstresswerealsosingnificantlyassociatedwithprimarydysmenorrheaConclusion：InStudyOne，theresultsdemonstratedthatprimarydysmenorrheaWasheritableTheeffectsofgeneticfactorswerediffe