77例直腸癌伴肝轉(zhuǎn)移患者的臨床預(yù)后分析.pdf

1、新疆醫(yī)科大學(xué)碩士學(xué)位論文77例直腸癌伴肝轉(zhuǎn)移患者的臨床預(yù)后分析姓名：孫毅申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：腫瘤學(xué)（放療）指導(dǎo)教師：包永星2010-04新疆醫(yī)科大學(xué)醫(yī)學(xué)碩士學(xué)位論文 — 2— Prognostic Analysis of 77 Rectal Cancer Cases with Synchronous Liver Metastases Postgraduate:Sun Yi Supervisor:Prof.Bao

2、 Yong- xing Abstract Objective: To explore the prognostic factors for rectal cancer patients with synchronous liver metastases. Methods: Data from a total of 77 rectal cancer patients with synchr

3、onous liver metastases treated at Xinjiang Medical University from January 2002 to December 2008 were collected and reviewed. The total survival rate was analyzed by Kaplan- Meier method, Log- ran

4、k method and Cox regression model with SPSS17.0 software were used to analyze 13 factors including clinical pathological factors and treatment choices. Results: The median survival time of 77 p

5、atients with synchronous liver metastases from rectal cancer was 12 months. The 1 - , 2 - , 3 - and 5 - year survival rates were 47.70%, 28.80%, 13.10%, and 1.50% respectively. Univariate analysis

6、 with Kaplan- Meier methods revealed that the differentiation of the primary tumor, T - stage, N status, the distribution、number and size of liver metastases, extrahepatic disease, serum CEA level

7、 at diagnosis and treatment modality were prognostic factors（P<0.05). Multivariate analysis showed that the differentiation of the primary tumor（P=0.007), T - stage（P=0.027), the size of liver m

8、etastases（P=0.003), serum CEA value at diagnosis（P=0.000) were independent prognostic factors for rectal cancer patients with synchronous liver metastases. Conclusion: The factors affecting the progn

9、osis for rectal cancer patients with synchronous liver metastases are the differentiation of the primary tumor, T- stage, N status, the distribution、number and size of liver metastases,extrahepatic

10、 disease, serum CEA level at diagnosis and treatment modality; the independent prongostic factors are the differentiation of the primary tumor, T - stage, the size of liver metastases, serum CEA