血漿P-選擇素、血栓調(diào)節(jié)蛋白在彌散性血管內(nèi)凝血中的動態(tài)變化及臨床意義.pdf

1、南開大學(xué)碩士學(xué)位論文血漿P選擇素、血栓調(diào)節(jié)蛋白在彌散性血管內(nèi)凝血中的動態(tài)變化及臨床意義姓名：沈中華申請學(xué)位級別：碩士專業(yè)：內(nèi)科學(xué)指導(dǎo)教師：曹書華2001.5.1南開大掌醫(yī)學(xué)院碩士研究生畢業(yè)(掌位)論文————————————————————————————————————————————————————————————————一一VariationsandClinicalSignificanceofPlasmaP—selectinand

2、ThrombomodulininDisseminatedIntravascularCoagulationGraduate：ShenZhonghuaSupervisor：CaoShuhuaAbstractobjective：TomeasuretheplasmalevelsofsP—selectinandTMinpatientswithdisseminatedintravascularcoagulation(DIC)andevaluatet

3、hesignificanceofthemindiagnosisandprognosisofDICMethods：PlasmasPselectinandTMwerebothmeasured、ⅣitllELISAinDICgroup(7cases)andsuspectedDICgroup(23cases)atthemomentwhenthediagnosiswasmadeandontheday23，5，7afterthediagnosisr

4、espectivelyResults：PlasmalevelsofsPselectinandTMweremarkedlyhigherinDICgroupthanincontrolgroupPlasmalevelsofsP—selectinandTMweremarkedlyhigherinsuspectedDICgroupthanincontrolgroupPlasmalevelsofsPselectinandTMweremarkedly

5、higherinpatientswithDICthaninthosewithoutDICPlasmalevelsofTMweremarkedlyhigherinpatientswi也pooroutcomethaninthosewithgoodoutcomewhilesPselectinhadnosignificantdifferencebetweenthepatientswitIldifferentoutcomesThereWasapo

6、sitivecorrelationbetweenplasmalevelsofsP—selectinandTMConclusion：ThereareplateletactivationandvascularendothelialcellinjuryinDICandearlystageofDICThedeterminationofplasmalevelsofsP—selectinandTMisusefulforearlydiagnosisa