吸煙對急性冠脈綜合征及健康人群中CRP和IL-6水平的影響.pdf

1、subject: Acute coronary syndrome(ACS) is one common kind of pathological change, the inflammation is in great related with it. The smokers' morbidity and mortality is 2～6 times higher than the unsmoker. This research pla

2、ns to through the observation of the vivo C-reactive protein (CRP) and the Interleukin-6(IL-6) level in the acute coronary syndrome patients' active stage and the healthy crowd smoke group ,control group, confirm the rel

3、ationship between the inflammation and the ACS ,and whether or not could smoke and the inflammation factor be related.In clinical work. We can judge coronary disease patients' condition by the two factor, together the st

4、ability and the serious degree, forecast healthy crowd's chance of have the acute cardiovascular event.Method: Illness group is 42 cases, include unstable angina pectoris and acute myocardial infarction patients, using t

5、he international heart disease academic society and the association and the World Health Organization (ISFC/WHO) the clinical naming standardization union group formulates "the ischemia heart disease naming and diagnosis

6、 standard", within 24 hours after the chest pain attack, take early morning empty stomach elbow venous blood 4mi. Control group 47cases, took the same amount at the same time. Defers to smoking or not grouping separatel

7、y.Tests hs-CRP and IL-6 with the euzymelinked immunosorbent assay method, and carries on the comparison and the statistical analysis.Result: The serum level of hs-CRP and IL-6 in ACS group was higher than that in control

8、 group (P＜0.01). In ACS group, the serum level of smokers was higher than that of unsmokers(P＜0.05).And in smokers' group, the serum level of ACS patints was higher than that of the healthy crowd(P＜0.01). There was signi

9、ficant difference.Conclusion: ACS group blood serum level of hs-CRP and IL-6 obviously is higher than control group, explained hs-CRP and IL-6 are the reliable indicator of inflammation reaction. Level of them has a posi

10、tive relation with ACS. In the ACS group smoker blood serum level of hs-CRP and IL-6 obviously is higher than the Non-smoker, explained smoking related to coronary artary inflammation reaction, also with the coronal athe

11、rosclerosis mottling instability. But in the smoker ACS group blood serum level of hs-CRP and IL-6 obviously is higher than control group,explained smoking is not inflammation reaction's only related factor, possibly is