2047.環(huán)己二胺衍生的吡哆醛季銨鹽催化劑的發(fā)展及其仿生催化甘氨酸酯對亞胺的不對稱加成

1、學校代碼：10270分類號：062學號：142200728碩士學位論文環(huán)己二胺衍生的吡哆醛季銨鹽催化劑的發(fā)展及其仿生催化甘氨酸酯對亞胺的不對稱加成學院：生命與環(huán)境科學學院專業(yè)：有機化學研究方向：不對稱催化研究生姓名：趙濬宇指導教師：趙寶國完成日期:2017.3AbstractShanghaiNmalUniversityMasterofScienceIIAbstractAsakindofaminoacidschiralαβdiaminoa

2、cidsarechemicallybiologicallyimptantcompoundswithwideapplicationsinmanyareas.Thesynthesisofαβdiaminoacidsisstillachallengeinganicsynthesisitishighlydesirabletodevelopefficientenvironmentfriendlysyntheticmethods.Inbiologi

3、calsystemVitaminB6basedenzymescancatalyzedirectaldoladditionofglycinetoaldehydestofmchiralβhydroxy?aminoacids.InspiredbythebiologicalprocesswefocusedonbiomimeticasymmetricMannichadditionofglycineestertoiminestopreparechi

4、ralαβdiaminoacidsbyusingNquarternizedchiralpyridoxalsasthecatalyst.Thestudiesincludethefollowingseveralparts.(1)ByintroducingchiralcyclohexanediamineasthechiralcontrolelementwedevelopedaclassofnewchiralNquarternizedchira

5、lpyridoxalswithdifferentsidearms.TheNquarternizedchiralpyridoxalsarecatalyticallyactivefasymmetricMannichadditionofglycineestertoimines.(2)Thereactionparametersincludingcatalystsolventtheamountofwaterbaseweresystematical

6、lyinvestigatedftheasymmetricMannichadditionofglycineestertoimines.(3)Undertheoptimizedconditionssubstratescopewasinvestigated.Avarietyofchiralβhydroxy?aminoacidesterswereobtainedin39%98%yieldswith45%71%ee’smoderatediaste