P16，cyclinD1和cdk4在涎腺癌組織中的表達(dá)及意義.pdf

1、安徽醫(yī)科大學(xué)碩士學(xué)位論文P16，cyclinD1和cdk4在涎腺癌組織中的表達(dá)及意義姓名：胡萬(wàn)金申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：病理學(xué)與病理生理學(xué)指導(dǎo)教師：張洪福周健20030401安徽匡科大擘碩士學(xué)位論文TheExpressionofPl6，CyclinDlandCdk4inSalivaryGlandCarcinomaandTheirSignificanceabstractobjeetiveTostudythesignificanceande

2、xpressionofp16，cyclinD1andCDK4innormalsalivaryglandandsalivaryglandcarcinomaMethodsTheexpressionofp16，cyclinD1andcdk4in10normalsalivarygland，30mucoepidermoidcarcinoma，and30adenoidcysticcarcinomaweredetectedbyimmunohistoc

3、hemicalsPassay。ResultsTheexpressionrateofpl6innormalsalivaryglandandsalivaryglandcarcinomawere90％and38％respectivelyThereWaSasignificantdifferencebetweenthem(p001)Theexpressionrateofp16haddecreasingtrendinsalivaryglandcar

4、cinomaTheexpressionrateofcyclinDlinnormalsalivaryglandandsalivaryglandcarcinomawefe20％and80％respectivelyTherewasasignificantdifferencebetweenthem(p001)TheexpressionrateofcyclinDlhadincreasingtrendinsalivaryglandcarcinoma

5、Theexpressionrateofcdk4innormalsalivaryglandandsalivaryglandcarcinomawere30％and88％respectivetyTherewasasignificantdifferencebetweenthem0O01)Theexpressionrateofcdk4hadincreasingtrendinsalivaryglandcarcinomaInsalivarygland

6、carcinoma，withthedecreasingoftheexpressionrateofp16，theexpressionrateofcyclinDlandcdk4hadincreasingtrendAninversecorrelationwasfoundbetweentheexpressionofp16andcyclinDl，cdk4(p005)Withtheincreasingoftheexpressionrateofcyc

7、linDl，theexpressionrateofcdk4hadincreasingtrendAnpositivecorrelationWaSfoundbetweentheexpressionofcyclinDlandcdk4(pO05)P16，cyclinDlandcdk4werenotcorrelatedwithpatientsageandhistologicaldifferentiationConclusionsThedecrea