子癇前期患者胎盤組織及血清中TGF-β1的表達(dá)及臨床意義.pdf

1、分類號(hào)：714.256密級(jí)：非密UDCUDC：610學(xué)校代碼：11065碩士學(xué)位論文子癇前期患者胎盤組織及血清中子癇前期患者胎盤組織及血清中TGFTGFβ1的表達(dá)及臨床意義的表達(dá)及臨床意義史翠霞指導(dǎo)教師齊衛(wèi)紅副主任醫(yī)師學(xué)科專業(yè)名稱婦產(chǎn)科學(xué)論文提交日期2016年4月12日論文答辯日期2016年5月27日答辯委員會(huì)主席楊興升教授AbstractObjectiveAnalysisoftransfminggrowthfact1(TGF1)inp

2、atientswithpreeclampsiaplacentaexpressionclinicalsignificanceofplasma.MethodFebruary2013toFebruary2014periodinaffiliatedhospitalofQingdaoUniversityinthetreatmentof48patientswithpreeclampsiastudymildpreeclampsia25casessev

3、erepreeclampsiain23casesexcludethecomplicationcomplication.Romly34casesofnmalpregnantwomeninthecontrolgroupruleoutcomplicationsothercomplications.TakenonthreeteamsofpregnantwomenserumlevelsofTGF1detectionlocalizationexpr

4、essionofTGF1inplacentatissueproteinanalysis.Bydoubleantibodyswichenzymelinkedimmunosbentassay(ELISA)fdeterminationofserumexpressionofTGF1in.MarkusingWesternblothybridizationTGFβprotein1expressioninplacenta.Whileinpatient

5、swithpreeclampsiaplacentaserumlevelsofTGF1lowcrelationwiththeonsetseverityofpreeclampsiawereanalyzed.Results1.ObservationgroupinthemildseverepreeclampsiaplacentatissueexpressionofTGF1washigherthanthatinthecontrolgroupP=0

6、.008(P0.01)therearesignificantdifferences.2.GroupweightplasmalevelsofTGF1inseverepreeclampsiawerehigherthanthoseinthecontrolgroupcomparedifferencesP=0.02(P0.05)withstatisticalsignificance.3.Agroupofseverepreeclampsiaplac

7、entaexpressionofTGF1inplasmathanmildpreeclampsiagroupP0.05wasstatisticallysignificant.4.InplacentatissueofpatientswithpreeclampsiaTGFbeta1expressionwerepositivelycrelatedwithserumlevelsofTGFbeta1（r=0.789，t＝3.021，P＜0.01）.

8、Conclusion1.TGF1isinvolvedintheoccurrencedevelopmentofpreeclampsiamainlyproducesactsontheplacentareleasedintotheplasma.2.thepatientsillnesshasaverycloserelationshippositivelycrelated.3.Inpreeclampsiainpregnantwomenplasma