可溶性endoglin在子癇前期患者胎盤組織中的表達及意義.pdf

1、青島大學碩士學位論文可溶性endoglin在子癇前期患者胎盤組織中的表達及意義姓名：邢寶相申請學位級別：碩士專業(yè)：婦產科學指導教師：葉元華20100530TheexpressionofSolubleendoglinintheplacentaltissuesofpreecalmpsiaAbstractObjectiveToinvestigatetheexpressionofsolubleendoglin(sEng)inthePlacent

2、aofpreecalmpsiaMethodsInthestudywerecruited67womenwithpreeclampsiawhodeliveredintheDepartmentofObstetrics，AffiliatedHospitalofQingdaoUniversityMedicalCollegeFromJuly2008toJanuary2009，including31womenwithmoderatepreeclamp

3、sia(MPEgroup)and36womenwithseverepreeclampsia(SPEgroup)And39healthypregnantwomenweretakenascontrolgroupEnzyme—linkedimmunosorbentassay(EHSA)wasusedtomeasuretheserumconcentrationsofsEngSemiquantitativeRTPCRandWesternblotw

4、ereusedtoinvestigatetheexpressionofsEngmRNAandproteininplacentaResults(1)TheserumconcentrationsofsEnginMPEgroup【(1366_246)∥g幾】andSPEgroup【(1639_205)∥g／L]，weresignificantlyhighercomparedwithcontrolgroup【(952_069)∥g／L(PO01

5、)1(2)TheexpressionofsEngmRNAinplacentaofMPEgroup(O82_005)andSPEgroup(O93_005)weresignificantlyhigherthanthatincontrolgroup[(O63_004)(PO01)】(3)TheexpressionofsEngproteininplacentaofMPEgroup(O77003)andSPEgroup(089005)weres

6、ignificantlyhighercomparedwithcontrolgroup[(063_004)(P001)】(4)InMPEandSPEgroups，theserumconcentrationsofsEngwerepositivelycorrelatedwiththelevelsofsEngmRNAandtheproteinofsEnginplacenta【(r=08878，07812；P001)、(，=O7598，07811

7、尸001)】ConclusionsIncreasedexpressionofsEngmRNAandsEngproteininPlacentacouldincreaseserumconcentrationsofsEng，whichmaybeinvolvedinthepathoanatomicalprocessofpreeclamsiaPostgraduate：BaoxiangxingDirectedbyprof：YuanhuaYeKeyw