手性農(nóng)藥對映體的分離及相互轉(zhuǎn)化的研究.pdf

1、河北科技大學(xué)碩士學(xué)位論文手性農(nóng)藥對映體的分離及相互轉(zhuǎn)化的研究姓名：武彤申請學(xué)位級別：碩士專業(yè)：化學(xué)工藝指導(dǎo)教師：張炳燭20090501河北科技火學(xué)碩十學(xué)位論文AbstractManypesticidesarechiralcompoundsandconsistofmixturesofenantiomershavingdifferentbiologicalactivityThestudyofseparationandenantiomeriz

2、ationofchiralpesticidesonenantiomericlevelhasgreatimportanceontheelucidationandevaluationofrelevantecologicaleffectaswellasecologicalriskofthesepesticidesinenvironmentInthispaper，theenantioseparationofforty—threechiralpe

3、sticidessuchasbifenthrin，phenothrin，cyphenothrin，fenpropathrin，fenvalerate，cyhalothrin，phenthoate，malathion，profenofos，prothiophos，fosthiazate，fonofos，isofenphos—methyl，fenamiphos，tebuconazole，flutriafol，myclobutanil，pac

4、lobutrazol，triadimefon，triadimenol，imazalil，dichlorprop—methylesterwerestudiedonChiralcelODHandChiralcelOJ—Hchiralcolumnsinthenormal—phaseHPLCmodeThechiralpesticidesincludingtwelvepermethrinpesticides，twelveorganophospho

5、ruspesticidesandeleventriazolepesticidesandeightotherpesticidesTheresolutionconditionswereoptimizedonthetwochiralcolumnsResolutionresultsofdifferentcellulosechiralstationaryphasesandchiralrecognitionmechanismwerefurthere

6、valuatedIsomerizationhasbeenfrequentlyobservedfromexposuretOcertainsolventsonlyatthediastereomerleveHowever，SOfar，or窯anophosphoruspesticidesisomerizationcausedby‘solventshasnotbeencharacterizedattheenantiomerlevelInthiss

7、tudy，wecharacterizedthestabilityofstereoisomersfromsixcommonlyusedorganophosphoruspesticides，malathion，phenthoate，profenophos，fonofos，fenamiphos，pyraclofosduringhighperformanceliquidchromato伊aphy(HPLC)analysisandsamplepr

8、eparationToulteriorcomparethemechanismofisomerization，fenpropathrin，dichlorprop—methylesterandquizalofop—ethylwhichhavesimilarstructureswiththeorganophosphoruspesticidesweredetectedalsoStereoisomersofprofenophos，fonofos，

9、fenamiphos，pyraclofos，dichlorprop—methylandquizalofop—ethylwerefoundtobestable，butthoseofmalathion，phenthoateandfenpropathrinwereunstable，underheatorinorganicsolventsorinwaterRapidenantiomerizationofmalathion，phenthoatea

10、ndfenpropathrinwasobservedinmethanolandethanolbutnotinisopropanol，n—hexane，acetone，ormethylenechlorideIsomerconversioninvariablyoccurredattheaCposition，causingtheanalytestereoisomertOconverttOanepimerAndtheeffectofpHvalu