PPARs激動劑羅格列酮對大鼠癲癇持續(xù)狀態(tài)海馬神經(jīng)元的保護(hù)作用.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文PPARs激動劑羅格列酮對大鼠癲癇持續(xù)狀態(tài)海馬神經(jīng)元的保護(hù)作用姓名：牛海雁申請學(xué)位級別：碩士專業(yè)：神經(jīng)病學(xué)指導(dǎo)教師：鄭輯英20100315碩士學(xué)位論文ProtectiVeEffectsofperoxisomeproIiferatorsactivatedreceptors(PPARs)agonistrosiglitazoneonhippocampaIneurotoninstatusepiIepticusratsAb

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6、協(xié)ol舯up(n=6)Eac_h罌’oupis仃eated、ⅣimmemethodofgavageThecontrol目oupandthemodelgroupare西venequalVolumesalineThemodel們她entgroupratsare百Vellrosi西itazonesolution(4mg／kg／d)Fivcday8mergavaged，Limi啪Chlodde(127mg俺，ip)waSⅫected18h塒or

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8、ours，wrhilet11eratsofmodelCon仃olgroup鋤dnonnalconl∞l掣‘oupwere百vIeIlsalTleVolumeofsalineThemodelcon昀l孕ouparldthemodel仃ea缸n饑tgroupratsweresa翻ficed，respectiVely，at12h24h，72h，7daRerSETllecon仃0lgroup眺werekilledtogetherwimratst

9、llatweresa嘶ficed12hafterSEThehippoc鋤pusofallstudyobjectwere百VenTUNELstainingt0measureapoptoticcenand百Venimmunohistoch鋤ist拶鋤alysistotestBcl一2，Bax，attlles鋤etimeⅡleratioofBcl2／BaXw嬲calculatedSPSSl3Oversionwasusedforstatisti