丁苯酞對(duì)大鼠腦缺血再灌注損傷后細(xì)胞色素-C表達(dá)影響的研究及意義.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文丁苯酞對(duì)大鼠腦缺血再灌注損傷后細(xì)胞色素C表達(dá)影響的研究及意義姓名：王建華申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：神經(jīng)病學(xué)指導(dǎo)教師：劉瑞珍20100310山西醫(yī)科大學(xué)碩十學(xué)位論文Theexpressionofc”ochrome—canditssignilEicanceinthetreatmentofBu鑼lphthalideoncerebralischemia—reper如sion螄u巧AbstractobjectiVe：cere

2、bralischemi婦per觚ion叫u巧andprogr鋤rnedcendeathhavec10serehtio瑪rrlitochondriacoIlstitutethecontrolcenterofsurviVal，i11theIIlitochondriadependem印optosispathray，c”ocllroⅡle—creleased舶mIIlitochondria缸o(hù)thec)，poplasmisthehportant

3、processofapoptosisButylphtllalideiSthefirstchemicaldrugwithifldependent硫ellectualprop鰍yrightsiIlChiIlaInthisstudy，uSh培di腩rentnlethodstoobservetheeXpressionofc”ocIlromeciIlButylphthalideonfocalcerebralischemiareper缸sionir

4、ljllry’andexploreButylphtllalideprotectivee航ctonnerVecells，proVideexperimemaleVidenceforpreVentionandtreatlnentofcerebfovasculardiseaseMethods：l80IIlaleWistarralswerer鋤dolnlydiVided硫os11amoperatedgroup(n_36)，modelgroup(n

5、36)，Butylphtllalidetreatmemgroup(n_36)，ButylpIltllalidepreVention鏟oup(n_36)，B嘶lphtllalidepreVentiontr‘：atmem伊oup(n236)，each伊oupis脅herdiVidedi11toischellliareper凡sion6k12也24hthreesub一鏟oupsUs岫gInodifiedInethodtomake南calcer

6、ebralischemiarepermsionmodeLBut)，lphtllalidemeasuredby80rng／l(gdoseI面ectButylphtllalidedilutionby硫r印eritonealaRerlhischemiaiIlButylphtllalidetreatmentgroup；oneweekbe旬retheoperatio瑪withacontilluousgavageonceadayi11Butylph

7、tllalidepreVention鏟oup；withacom豳∞uSgavageonceadayone、Ⅳeekbe南retheoperation鋤d岫ectButylpht量lalidedilutionby硫raperitonealmer1hischemiaiIlButylphtllalidepreVentiontreatnlemgroup；iIlsllamoperalion掣oup鋤dmodel伊oup，硒ecttbesaInes

8、alineafter1hischemiaBraillpathologywithHEsta血iIlg，obsen，ethecllal喀eofcytochroIneci11bramtissuewithimmuneStailliIlg，detectapoptoticcellswithTUNELResults：1Usingmodi托dsuturemethodcallproduceMACO瓜nlodelsuccessmlly，focalische

9、micbrailltissuecanbeobseⅣedobViously2Therearedi彘rentdegreesofedemaandcaVity向m蚍ionscatteredh1theischemicbrailltissueofcerebralischemiarepermsionmodel伊oup，thenulllberofapoptoticcellsi11creasedsigm&antlyTherearevar)，ingdegr

10、eesofilnproVemem證preventionandtreatment伊oup3Comparewithsh甜n—operated鏟oup，cytochroIne—cexpressionaIldthe肌mberof印optoticcellsiIlcreaSedsignificantlyiIlthecerebralischemiareper如sionmodelgroup；iIlthepreVentiongroup，協(xié)；atmentg