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1、FewdTheperiodofintrauterineneonatalbraindevelopmentiscrucialfeverythingthatwewillbecomecanaccomplishintherestofourlife.Inthatshtperiodoftimetheoutlineofthehumanbraindevelopsintoatremendouslycomplexganconsistingof100billi

2、onneuronseachmakingbetween1000100000contactswithotherparticulargroupsofneuronsbymeansofsome100000kmofnervefibers.Eachgroupofneuronshastobebnattherightmomentmigratetothesitewheretheydifferentiatemaketheirspecificcontactsi

3、nalimitedcriticalperiodofbraindevelopmentindertofunctionlaterinanmalway.Buildingsuchacomplexstructureasthebraininsuchabriefperiodiscertainlyamostdemingtaskfnature.Itisinfactawonderthatitdoesnotoftenendwithcatastrophicfai

4、luresinoneofthenumerousexactlytimedextremelycomplexprocessesinsteaditmostlyresultsinahealthybabywithgoodpotentialftherestofitsexistence.ThepresentvolumeoftheHbookofClinicalNeurologyeditedbyHarveySarnatPaoloCuratolodealsw

5、iththosechildreninwhombraindevelopmenthasresultedinamalfmationofthecentralnervoussystem.Thisfieldhasrecentlygainedexcitingnewinsightsfinstancefrommoleculargeicswhichareintegratedinthisvolume.SectionIofthisvolumefollowsth

6、enewintegrativeclassificationdealswithlinehypoplasiasdisdersofsegmentationoftheneuraltubehamartomatousdisdersofcellularlineagedisdersofradialneuroblastmigrationcerebralcticalarchitectureotherdysgeneses.SectionIIdescribes

7、thedifferentclinicalmanifestationsofCNSmalfmationsfollowedbysectionsondiagnosticmethodsmanagementtreatment.TheeditsofthisvolumeofthethirdseriesoftheHbookofClinicalNeurologyaretobecongratulatedinbringingtogetherawiderange

8、ofinternationallyacknowledgedexpertstodescribethenewdevelopmentstheirclinicalimplications.Wearegratefultotheauthswhoseexcellentchaptersarethebasisfthisvaluablevolume.InadditionweareofcoursealsogratefultotheteamatElsevier

9、–inparticulartoMsLynnWattMrMichaelParkinsoninEdinburgh–ftheirexpertassistanceineverystageofthedevelopmentproductionofthisvolume.MichaelJ.AminoffFrancoisBollerDickF.SwaabListofcontributsC.ArpinoTVergataUniversityofRomeRom

10、eItalyK.M.BarlowUniversityofCalgaryAlbertaChildren’sHospitalCalgaryAlbertaCanadaP.G.BarthEmmaChildrensHospitalAcademicMedicalCenterUniversityofAmsterdamAmsterdamTheherlsG.BattagliaNeurologicalInstituteC.BestaMilanItalyE.

11、BoltshauserUniversityChildren’sHospitalZurichSwitzerlR.BombardieriTVergataUniversityofRomeRomeItalyM.H.CarstensCardinalGlennonChildren’sHospitalSaintLouisUniversitySaintLouisMOUSAC.CerminaraTVergataUniversityofRomeRomeIt

12、alyS.CianfaraniTVergataUniversityofRomeRomeItalyP.CuratoloTVergataUniversityofRomeRomeItalyG.diPietroOspedalePediatricoMeyerFlenceItalyP.A.DonatiOspedalePediatricoMeyerFlenceItalyL.FlesSarnatAlbertaChildren’sHospitalCalg

13、aryAlbertaCanadaL.GenitiOspedalePediatricoMeyerFlenceItalyF.GidanoOspedalePediatricoMeyerFlenceItalyJ.G.GleesonUniversityofCalifniaSanDiegoLaJollaCAUSAW.D.GrafChildren’sMercyHospitalsClinicsUniversityofMissouriKansasCity

14、MOUSAT.GranataNeurologicalInstituteC.BestaMilanItalyJ.S.HahnStanfdUniversitySchoolofMedicinetheLucilePackardChildrensHospitalStanfdCAUSAL.D.HamiwkaUniversityofCalgaryAlbertaChildren’sHospitalCalgaryAlbertaCanadaP.Humphre

15、ysChildren’sHospitalofEasternOntarioOttawaOntarioCanadaK.ImaiTheHospitalfSickChildrenUniversityofTontoTontoOntarioCanadaA.M.InnesUniversityofCalgaryAlbertaChildren’sHospitalCalgaryAlbertaCanadaR.LeventerRoyalChildren’sHo

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