14347.新型的天冬氨酰蛋白酶抑制劑yf0200ra和b的合成和研究

1、分類號UDC密級公開暑哦諍產篝碩士研究生學位論文新型的天冬氨酰蛋白酶抑制劑YF0200RA和B的合成和研究申請人：王曉丹學號：2131132培養(yǎng)單位：化學化工與材料學院學科專業(yè)：有機化學研究方向：藥物合成化學指導教師：侯艷君教授伍貽康研究員完成日期：2016年3月18日黑龍江大學碩士學位論文AbstractThisthesisintroducedthetotalsynthesisoftwonaturalunsaturatedfattya

2、cidswithaspargylproteaseinhibitionactivityTherelativeconfigurationandtheabsoluteconfigurationwereconfirmedBothofthesenaturalcompoundswerefirstlyseparatedfromsouthernSumatrasoilsamplesTheplanarstructureswerestudiedbynucle

3、armagneticresonance(NMR)，massspectrometryandotherinstrumentanalysismethods，buttherelativeconfigurationandabsoluteconfigurationwerenotdeterminedInthispapertwopartswerewrittentointroducetheprocessesoftotalpreparationoffour

4、compoundsTheprocessofpreparing(2E，4E，8R，10R)and(2E，4E，8S，1OR)一8，10，12一trihydroxydodeca2，4dienoicacidwasintroducedinthefirstpartDglucosewasusedasrarematerialtOinstallepoxychiralbuildingblocksThefinalproductionwassynthesiz

5、edbyradicalmediateddeoxygenation，Homer—Wadsworth—EmmonsreactionandotherreactionsTheabsoluteconfigurationsfornaturalYF一0200RBcouldbereliablyassignedas(ss，10S)byanalyzingthespectroscopicdata，IHNMRand13CNMRInthesecondpart，(

6、8R，2E，4E)and(8S，2E，4E)一8，12一dihydroxydodeca一2，4dienoicacidweretotallysynthesizedDuringtheprocess，asymmetricailylation，hydroboration，oxidationandHomerWadsworthEmmonsreactionwereusedtopreparetheopticallyactivetargetcompoun

7、dswith(8R)and(8S)configurations，respectivelyAssignmentsoftheabsoluteconfigurations，(8s)，ofYF一0200RAweremadeonthebasisofcomparisonofthe1Hand13CNMRaswellasopticalrotationsKeywords：naturalproducts，totalsynthesis，chiralpool，