VEGF-C對乳腺癌淋巴結轉移的影響.pdf

1、山西醫(yī)科大學碩士學位論文VEGFC對乳腺癌淋巴結轉移的影響姓名：呂俊申請學位級別：碩士專業(yè)：外科學指導教師：趙瑛20080420山西醫(yī)科大學碩士學位論文VEGFCfortheimpactofbreastcancerAbstractobjeetive：BreastcancerisaconHnonmalignancyofwomenoneofitsrecurrenceandmetastasisareaffectingqualityoflife

2、andsurvivaltimeallimportantreasonRecentstudieshavefoundthatbloodvesselsandlymphaticformationandtheoccurrenceofbreastcancercloselyrelatedtothedevelopmentandprognosisInrecentyears，thetumorangiogenesisandlymphangiogenesisre

3、searchandmoreconcentratedintheVascularendothelialgrowthfactoronthefamilyVascularendothelialgrowthfactor(VEOF)鈾舊consideredtostimulatevascularendothelialcellsproliferationoneofthemostimportantfactors，promotingitasaspecific

4、angiogenesisandvascularpermeabilityfactorintumorinducedangiogenesisandmetastasisoftheroleofotherspeoplearesubjecttoahighdegreeofattentionBasedonthe40casesofbreastfibroadenoma，aswellas80casesofhumanbreastcancerpatients、析t

5、hinvasiveductalcancerofvascularendothelialgrowthfactorC(VEOFC)testing，aimedatexploringVEGF—ContheimpactoflymphnodemetastasisofbreastcancerAnalysisofbreastcancertissueandtumorwithinthelymphatictissuegrowthfactorinthediffe

6、rentexpressionofaxillarylymphnodemetastasisandtherelationshipbetweentheexplorationlymphangiogenesisintumorsinthelymphnodemetastasistothepossiblemechanismfortheclinicaljudgementofwhetherbreastcancerlymphnodemetastasisprov

7、ideanewandeffectivemethodMethods：ByimmunohistochemicalEnvisionof80casesofhumanbreastinvasiveductalcarcinomaand40patientswithbreastfibroadenomaoftheparafifinsectionweretestedtoobservetheexpressionofVEGFCstatusWereanalyzed

8、byopticalmicroscopyimmunohistocbemicalstainingresultsThenstatisticalanalysisofthespecimenswithlymphnodemetastasisandnolymphnodemetastaseswerefoundtoexpresstheexistenceofdi毹rencesResults：Breastfibroadenomaandbreastdisease

9、tissuewerenotfoundVEGFCexpression40patientswithbreastfibroadenomawerenegativeVEGF—C，80casesofbreastcancerinvEGF—C，thepositiveratewas725％(58／80)，ofwhichthereare52patientswithlymphnodemetastasis，ⅦGFC，thepositiverate808％Wim

10、lymphnodemetastasisofbreastcancertheexpressionofvE(珂CandwithoutlymphnodemetastasisgroupexpressionWashighlysignificantdifferenceVEGFCexpressioninprimarybreastcancercellcytoplasm，thepositiveresultforthebrightbrowngranulara