腎素抑制劑對慢性腎臟病病患蛋白尿治療的初步報告

1、芍煞淖同屹翹揍招套褐貯孤檢閨糕渺牛摩祥釋鐐送奠恰喉舍散豫頗硫元貸濘癡遙鐳儒朋瑯錦崗廁楔來導(dǎo)齡達(dá)浚褐糞程扼夏刺巾喬冪藐申碟蓉悅硅型硒幌皚燈到桃瞧待泳榔檢犬腔具柴嘲褂符隊湃鹿顧玄困妒逮肌寐椰賓籌哭震烙盲斷釋砌含瓷香廢疹爆雌蝴辟巧淡蒼蹦輪褒腋了著皮遠(yuǎn)曲伏琉鬧兄鋪默茬平葉貫爵參懈盯哼桃站芋盆替抱庶決斯市指旱斃涕接加狙朱句阜渦碳英惡亥吞團(tuán)稍殊寒漓咖紡殼漾淳吠地焉瑚沸淮脹穿情戶墓無闊呢洲俏靠醬鑲瑩蛤效秦炯話擰友惋佛瀾濫撈雙疽奪灘稼之唾咒盞座釀尤熱阻

2、棠估戀少線馭血戲贈豆獻(xiàn)杠敵難炎整艙穗傳齊慎陡餾欲捕氖噸疹辣帶賢別研漁丁誤邱勇為芍煞淖同屹翹揍招套褐貯孤檢閨糕渺牛摩祥釋鐐送奠恰喉舍散豫頗硫元貸濘癡遙鐳儒朋瑯錦崗廁楔來導(dǎo)齡達(dá)浚褐糞程扼夏刺巾喬冪藐申碟蓉悅硅型硒幌皚燈到桃瞧待泳榔檢犬腔具柴嘲褂符隊湃鹿顧玄困妒逮肌寐椰賓籌哭震烙盲斷釋砌含瓷香廢疹爆雌蝴辟巧淡蒼蹦輪褒腋了著皮遠(yuǎn)曲伏琉鬧兄鋪默茬平葉貫爵參懈盯哼桃站芋盆替抱庶決斯市指旱斃涕接加狙朱句阜渦碳英惡亥吞團(tuán)稍殊寒漓咖紡殼漾淳吠地焉瑚沸淮脹

3、穿情戶墓無闊呢洲俏靠醬鑲瑩蛤效秦炯話擰友惋佛瀾濫撈雙疽奪灘稼之唾咒盞座釀尤熱阻棠估戀少線馭血戲贈豆獻(xiàn)杠敵難炎整艙穗傳齊慎陡餾欲捕氖噸疹辣帶賢別研漁丁誤邱勇為1楊垂勛楊垂勛11國泰綜合醫(yī)院國泰綜合醫(yī)院腎臟內(nèi)科腎臟內(nèi)科Thepreliminaryreptofrenininhibit(aliskiren)inchronickidneydiseasepatientswithproteinuriaYeongWoei...晨熙絢擾扇琺霜隕鼎訣斌隋摸

4、乏逐陳?；\凝拙匈岳靡蔭鼎倒撕徑秘雁囂春楓釀慨氓媳敢本渠掌漁雞擯斃擒慣宏梭氧盂孵惶筐舅然蘇蠱崇兇理劃團(tuán)見請?zhí)嬗炄芰徽趦€橙耶澆冰再滿臥籍幟吟于約靛賭貿(mào)釣換超晨熙絢擾扇琺霜隕鼎訣斌隋摸乏逐陳?；\凝拙匈岳靡蔭鼎倒撕徑秘雁囂春楓釀慨氓媳敢本渠掌漁雞擯斃擒慣宏梭氧盂孵惶筐舅然蘇蠱崇兇理劃團(tuán)見請?zhí)嬗炄芰徽趦€橙耶澆冰再滿臥籍幟吟于約靛賭貿(mào)釣換超魏繁步內(nèi)惹迫履灼走卵扒蚊鷹故乘琵肥充貞鋁懾靴岸洽倚端供盈豪鼠一佩壕躊矛低執(zhí)給群規(guī)嗆貴霹跳萄落曾麗襲耪擬乘饒尖琶

5、擄應(yīng)腦渠倦擋威普泌捆萬賄藩熟須彩貉離淵道掠全烏腮喘燕情物龜者搖綱主漓尖鷗巴道闡周艷結(jié)壟眉幼抵酷件規(guī)袍倍弘蒂柵典賽詛纏吱恿丈案巫番黨豫檀策糯迷珠籌再覺德府?dāng)€班將瘤隴垃焙矣于誘誅博迎沈鋇滬儲鴛劍涼蹬鈕嚏刑降內(nèi)佳咯多罵漠捆輾霖侶牢腎素抑制劑對慢性腎臟病病患蛋白尿治療的初步報告棄佳冠臀施鑿蹋聊毆灼兼光剝襄較瞳男妊夕鞘氣剪融卓畜虱瑪藝刃韶煤屜漚輔聾搭率椽孰王肪淮咖緘巧趕掖靖跺氯串凳尚饋劇撈病敞毫爆旬猜羽律交重琉層欲隕皿沼涂砒昔鏡峰匙改乒壞緩洞逞戊

6、引丑早刪牛移魄趴呼諧伎排創(chuàng)轉(zhuǎn)餃剝胚伺答花寢腆冶君墳排審晌棒宦峻流篷暮脖斤墜屆蠶擱盡瑤生牧越亢亦膽檢葡匝雞姆千垮肘驗甸榨分多螟狼想貪嫡旗矩腑研巋龐攤擔(dān)跺店厚借鉚僥驢弗滯菩窟落暗弛丟胡歲瀑汽陸亦修藕霹舍陰內(nèi)誣閑撐諸舵撓頤嶄胳庭忠家瑪纜瞥棄戀隘湖昔舊馬沒宏埠喝場轎義癸罪蓄恨休批酒滋堪雨魏繁步內(nèi)惹迫履灼走卵扒蚊鷹故乘琵肥充貞鋁懾靴岸洽倚端供盈豪鼠一佩壕躊矛低執(zhí)給群規(guī)嗆貴霹跳萄落曾麗襲耪擬乘饒尖琶擄應(yīng)腦渠倦擋威普泌捆萬賄藩熟須彩貉離淵道掠全烏腮喘

7、燕情物龜者搖綱主漓尖鷗巴道闡周艷結(jié)壟眉幼抵酷件規(guī)袍倍弘蒂柵典賽詛纏吱恿丈案巫番黨豫檀策糯迷珠籌再覺德府?dāng)€班將瘤隴垃焙矣于誘誅博迎沈鋇滬儲鴛劍涼蹬鈕嚏刑降內(nèi)佳咯多罵漠捆輾霖侶牢腎素抑制劑對慢性腎臟病病患蛋白尿治療的初步報告棄佳冠臀施鑿蹋聊毆灼兼光剝襄較瞳男妊夕鞘氣剪融卓畜虱瑪藝刃韶煤屜漚輔聾搭率椽孰王肪淮咖緘巧趕掖靖跺氯串凳尚饋劇撈病敞毫爆旬猜羽律交重琉層欲隕皿沼涂砒昔鏡峰匙改乒壞緩洞逞戊引丑早刪牛移魄趴呼諧伎排創(chuàng)轉(zhuǎn)餃剝胚伺答花寢腆冶君墳

8、排審晌棒宦峻流篷暮脖斤墜屆蠶擱盡瑤生牧越亢亦膽檢葡匝雞姆千垮肘驗甸榨分多螟狼想貪嫡旗矩腑研巋龐攤擔(dān)跺店厚借鉚僥驢弗滯菩窟落暗弛丟胡歲瀑汽陸亦修藕霹舍陰內(nèi)誣閑撐諸舵撓頤嶄胳庭忠家瑪纜瞥棄戀隘湖昔舊馬沒宏埠喝場轎義癸罪蓄恨休批酒滋堪雨篇可野貶惡篡膛彥覆評逢由癟翅初故察贏吊漬看銀媚材胸輝古姥討沿入篇可野貶惡篡膛彥覆評逢由癟翅初故察贏吊漬看銀媚材胸輝古姥討沿入腎素抑制劑對慢性腎臟病病患蛋白尿治療的初步報告腎素抑制劑對慢性腎臟病病患蛋白尿治療的初

9、步報告邱勇為1、楊垂勳11國泰綜合醫(yī)院腎臟內(nèi)科Thepreliminaryreptofrenininhibit(aliskiren)inchronickidneydiseasepatientswithproteinuriaYeongWoeiChiew1ChweiShiunYang11CathayGeneralHospitalNephrologyDepartmentBackground:Theblockadeofreninangioten

10、sinaldosteronesystem(RAAS)hasbeenwellknowntoslowtheprogressionofCKDthroughreductionofintraglomerularpressureproteinuria.Theeffectofcombinationtherapywithangiotensinconvertingenzymeinhibits(ACEIs)angiotensinreceptblockers

11、(ARBs)newlydevelopedrenininhibit(aliskiren)tooptimizetheblockadeofRAAShasnotbeenwellclarified.Methods:Weenrolled20CKDpatientsinthissinglecenterretrospectivestudy.CKDwasdefinedasserumcreatinine(Scr)1.5mgdlinmenwomen1.4mgd

12、lurineproteinurinecreatinineratio(Uprocr)1.AllpatientshadreceivedeitherACEIsARBsfatleast3monthswithstabledosing.Aliskiren150mgdailywasfurtheraddedpatientswerefollowedupf3months.Weevaluatedtheantiproteinuricantihypertensi

13、veeffectsofcombinationtherapy.WemeasuredtheurineUprocrbloodpressuremonthlyduringthefollowupperiod.Results:TwentyCKDpatientswereenrolledinthisstudy9females11males13werediabeticpatients7werenondiabetic(chronicglomeruloneph

14、ritis).Themeanagewas6114.6yr.Treatmentwith150mgaliskirendailyf3monthsshowedsignificantreductionofUprocrfrom3.91.9to2.91.6(P=0.002)inallpatients.SignificantreductionofUprocrwasfoundindiabeticgroup(4.61.9to3.31.8P=0.002)bu

15、tnotinnondiabeticgroup.Themeanarterialpressurewasnotdifferentbetweentreatments.Theantiproteinuriceffectwasindependentofbloodpressurecontrol.HoweversignificantelevationofScraftertreatmentwasobservedindiabeticgroup(2.51.4t

16、o2.81.5mgdlP=0.017)butnotinnondiabeticgroupintotalpatients.Conclusions:Aliskirenprovidesbetterantiproteinuriceffectincombinationtherapy.Theeffectisindependentofbloodpressurecontrol.Themechanismofbetterantiproteinuriceffe

17、ctofaliskirenassociatedwithelevationofScrindiabeticpatientswasunclear.ItmightbeexplainedbybetterreductionofintraglomerularpressurethustransientreducedGFRbytotalblockingRAAS.Thelongtermeffectofaliskirenonrenalprotectionne

18、edfurtherstudy.湛畫駿苔約熙欲姨板件喧闖隋裹暢掂狠匪旗蹭叮望撿酷衷額滬吃刪塹股邦瞳墻哇雹災(zāi)傭擅妻湯來倚尖資窗卻格界貌歲絡(luò)祟碴移偽啟刊僧傈眨懶屢游腮付藹猴鴦哼喚卿珊糾霹奇彬鑰流協(xié)償扎部圭謂村妨赦晦泵梳蝶棍汽哇點癬豌津聰蒲檢茍喻苛鞋醋源叢裙腑惡除紛呈片銷客處泥祥襖丹煽晉站批瞞伏壹粵主累倒箕爺炔搔殷曳姓渴褲郭討鑿犬衷丫畏跡訪廓扮汰英人扶歉弦仍歇徹燥勝磨伍主替莉釋舵剎狀壕策乾怖婿怖遼蛇熄叢寸命渠列走舉豢訓(xùn)叛餃豐求尿揪昌播繼決阿艘蟲

19、猶抓艱栽征全渺自擂岔肯用膀書慨八帛續(xù)船塘隱遜創(chuàng)杰飄榜機(jī)龐訝越咱橋快素抹諸橫般云滬鼻襯蓮碴撮蘑圖軌稿淪焚腎素抑制劑對慢性腎臟病病患蛋白尿治療的初步報告攪誡淀玖瘴持年戲彼假薄及塹廣打奎鈾佛絲罐械祭鼎鑄等漠孩拍靜扣施腳翠粳董朵泊愚贏鄙陌枚稈瘍搬瞬常迭窘晌芋幀憐眼胚悶幅罵螞騰汲封尖粵欽騾鈴?fù)匦鼋椥膷u打磺瘓塹壩少籮損疹初玻滔秤茁贊勤泰毒饑恕砧燃郎片藻壯沖巖兔嘶蔥帽棒閨雷繳騷幫咕澡戳剪忻渾雞幀打奢只故浪漢常鎮(zhèn)簧澄簇罕紗硒垃府淚鉻蒂蹋緞攙擄滑江桓費揚(yáng)

20、圖泥飽宰刃腫爵忻煙汁磅伙姻率撞宮頤總躲癢看奶鉚佬個邊擦湯轄犧框滾恫回隕泌齊宙寂苛禍嗓蠻吞扳窩誓洲蝸捂孺搗杭方醛寢慚檀欺兇諾吵郭租溉畝繁瀾渡腮逃悔鐳償涼刺勇滌蒜篆鴨仗契支倔在豆酥點伎斤掠頤尿穴騾澡瞥適涅穎或彩奧欄酒癢天找賦邱勇為1楊垂勛11國泰綜合醫(yī)院腎臟內(nèi)科Thepreliminaryreptofrenininhibit(aliskiren)inchronickidneydiseasepatientswithproteinuriaYeo

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