5，6，7-三甲氧基取代N-取代芳環(huán)-4-胺基喹唑啉化合物的合成和抗癌活性研究.pdf

1、貴州大學碩士學位論文5，6，7三甲氧基取代N取代芳環(huán)4胺基喹唑啉化合物的合成和抗癌活性研究姓名：張英申請學位級別：碩士專業(yè)：有機化學指導教師：楊松宋寶安20080601貴州大學2008屆碩士學位論文AbstractWithPD153035astheleadingcompoundaseriesof56，7trimethoxy4(Nexyl)aminoquinazolinecompoundsweredesignedandsynthesize

2、dStartingfrom23，4trimethoxyhenzoicacidfollowedbynitrationesterificationreductioncyclizationandchlorinationkeyintermediate4chloro5，6，7trimethoxyquinazolineWasobtainedThendifferentsubstitutedanilineswe佗reactedwiththekeyint

3、ermediategivingthetitle56，7一Irimeth塒(y4(Naryl)aminoquinazolinecompoundsThestructuresofthetitlecompoundswereelucidiatedbyelementalanalysis，R1HNMRand13CNMRspectraMicrowavemethodandconventionalheatingmethodwerecomparedforth

4、esynthesisofa11thetitlecompoundsItWasfoundthatthetitlecompoundscouldheobtainedinshortcrreactiontimeandhighyieldswitheasierworkupprocedmebyusingmicrowavemethodPreliminarybioassayrevealedthatthetitlecompoundshadcertainacti

5、VityagainstPC3andBcap37cellproliferationAmongthemtheantiproliferationactivitiesofcompounds13，I‘，17I’l，InandI‘a(chǎn)gainstPC3cellwerefoundtohe317％，326％，58O‰389％，397％，496％，and346％at10pmol／LresepectivelyCompounditsshowedhighanti