鹽酸安非他酮的合成工藝研究.pdf

1、南京理工大學(xué)碩士學(xué)位論文鹽酸安非他酮的合成工藝研究姓名：趙金柱申請學(xué)位級別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：程廣斌20100501Abstract碩：論文AbstractInthispaper，bupropionhydrochloride，anewantidepressantandstop—smokingdrugs，wassynthesizedbyusingmchloropropiophenoneastheprimalmaterialThe

2、syntheticprocessundergotwosteps，includingmchloropropiophenone’Sbrominationandmchloro—O【bromopropiophenone’SaminationandacidificationOnthestepofbromination，threedifferentbrominatingagentswereinvestigated，includingbromine，

3、PyHBrBr2and[Bmim]Br3TheoptimalreactionconditionswereobtainedthroughoptimizingtestseparatelyThem—chloro—a—bromopropiophenoneWassynthesizedwithbromineasbrominatingagentTheyieldoftheproductWas974％anditspurityWas982％Theoptim

4、alreactionconditionswereasfollows：CH2C12assolvent，molarratioofm—chloropropiophenonetobromineWas1：102，TsOHascatalyst，theamountofthecatalystWas2％(massfraction)，reactionWascarriedoutfor15hat30℃andthebrominewasaddedin05hThem

5、—chloro一0【一bromopropiophenoneWassynthesizedwithPy—HBrBr2asbrominatingagentTheyieldoftheproductWas956％，anditspuritywas981％Theoptimalreactionconditionswereasfollows：ethanolassolventmolarratioofm—chloropropiophenonetoPyHBrB

6、r2Was1：12，reactionWascarriedoutfor3hat60(2，andthebrominatingagentwasaddedinfourThem—chloro一0c—bromopropiophenoneWassynthesizedwith【Bmim]Br3asbrominatingagentTheyieldoftheproductWas947％，anditspurityWas975％Theoptimalreacti

7、onconditionswereasfollows：molarratioofm—chloropropiophenoneto【Bmim]Br3was1：105，reactionWascardedoutfor05hat30℃ThebupropionhydrochlorideWassynthesizedthroughtheaminationoftbutylamineandmchloroabromopropiophenoneTheyieldof

8、theproductWasupon89％，anditspurityWasabout997％Theoptimalreactionconditionswereasfollows：NMPassolvent，molarratioofm—chloro一0【bromopropiophenonetbutylamineandhydrogenchlorideWas1：5：15，TBAIascatalyst，theamountofthecatalystWa