以取代茚基為配體的手性金屬催化劑的制備及其在不對(duì)稱催化反應(yīng)中的應(yīng)用

1、上海師范大學(xué)碩士學(xué)位論文以取代茚基為配體的手性金屬催化劑的制備及其在不對(duì)稱催化反應(yīng)中的應(yīng)用姓名：陸小泉申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：劉國(guó)華20090401上海師范大學(xué)碩士學(xué)位論文AbstractThechiralsecondaryalcoholsareimportantintermediatesinthesynthesisofdrug，pesticideandspiceryetc，andtherearenumerousmet

2、hodsremainthefocusofmuchresearchactivityCatalyticasymmetryadditionofaldehydesandasymmetryreductionofprochiralketonesaretwoeffectivemethodsforpreparationofchiralsecondaryalcoholsThesetwomethodsplayanimportantroleinacademi

3、cresearchandindustryTheimportanceofchiralityandthewaysofobtainingchiralcompoundswerebrieflyreviewedTheroleofligandsincatalyzedasymmetricreactionsandtheirclassificationwereelucidatedThreeunreportedchiralligandsinvolvedind

4、enylwereobtainedinthisthesisAndtheseligandswereusedtocatalyzeasymmetryhydrogenationofaromaticketonesandasymmetryallylationofaromaticaldehydewithdifferentkindsofmetallicsaltandchiraldiamineTheeffectivenessofthesecatalytic

5、systemswereassessedbythedatagotfromHPLCandGCThemainworkincludes1：Severaldifferentsubstitutedindenylligandswerepreparedfromindenyllithium(preparedbefore)anddifferentsubstitutedhalidesAnewkindofcatalyticsystemwasobtainedby

6、usinglithiumsaltsofindene，3butylindeneand3一(4一methylbenzyl)indenepreparedinsitutoreactedwithMCln(M=In，n=3；M=Zrn=4)，thencoordinatedwiⅡ1chiralBinaphth01Thecatalyticactivityofthiskindofcatalyticsystemwereassessedintheasymme

7、tryallylationofaromaticaldehydeTheoptimumreactionconditionwereobtainedbytryingdifferentsolventsandtemperaturesTheinfluencesofthesubstituentsofaromaticaldehydesandsubstitutedindenestotheeffectivenessofthecatalyticsystemsw

8、ereresearchedItwasfoundthatCatalyticsystemIndeneZrBinolshowedthebestresults，whichgave742％eeto1一(4methoxyphenyl)but3en1一012：LigandsSingleidene—BINIOL—MOMandDoubleindene—BINOL—MOMwerepreparedthroughmulti—stepreactions，then