2,4二取代苯基1，5苯并硫氮雜卓3甲酸乙酯的合成及抑菌活性研究(1)

1、河北師范大學(xué)碩士學(xué)位論文2，4二取代苯基1，5苯并硫氮雜卓3甲酸乙酯的合成及抑菌活性研究姓名：高俊月申請學(xué)位級別：碩士專業(yè)：有機化學(xué)指導(dǎo)教師：張萍20100406IVAbstract15Benzothiazepineisakindofcompoundwhichhasimptantphysiologicalactivities.Someofitsderivativeshavebeenusedinclinicasantianxietydru

2、gshyprosiscardiovularmedicines.Therefeitssynthesesstructurespharmacologicalactivitieshavebeenattractedwideattentions.15Benzothiazepineisthebasicskeletonofmedicine.Overthepastdecadetherehasbeendeepsystematicalresearchonth

3、efieldofexplingactive15benzothiazepinesinourlabary.Indertochoosebetter15benzothiazepinewithantibacterialactivitiessixteen3COOC2H5substituted15benzothiazepinearedesignedsynthesizedinthispaper.Themainjobsinthisthesisisasfo

4、llows:Fristlyaseriesofnovelethyl24disubstitutedphenyl15benzothiazepines3fmateissynthesizedbyfourstepswhereacetoaceticesterisusedasrawmaterials.AllthestructuresofthesecompoundsaredeterminedbyIR1HNMRMSxraysinglecrystaldiff

5、ractionmethod.Atlasttheiginalstructureactivityrelationshipisstudiedfthefoundationoffurtherresearch.Indertogetabetterresultreactionconditionsareoptimizedespeciallyftheprocesswhichhasanimptantinfluenceonthetechnology.Secon

6、dlythechalconesweresynthesizedbythereactionofethyllevulinatewithsubstitutedbenzaldehydes.ThechalconedonotreactwithoaminothiophenolbyconventionalMichaeladdition.Aseriesofeightmemberedcompoundswereobtainedinthereaction.Fin

7、allyWesummarizethelabatypreparatywk.Aseriesstudyonthereactionofchalconeoaminothiophenolarecarriedout.Thirdlytheantibacterialactivitiesoftheabove22newcompoundsweretestedinvitrobyusingoffilterpapermethod.KeyWds:15benzothia