利用多組分反應構建含吲哚基團的雜環(huán)化合物.pdf

1、蘇州大學碩士學位論文利用多組分反應構建含吲哚基團的雜環(huán)化合物姓名：趙愷申請學位級別：碩士專業(yè)：有機化學指導教師：紀順俊20100501英文摘要利用多組分反應構建含吲哚基團的雜環(huán)化合物TheConstructionofIndole—containingHeterocyclicSkeletonsviaOnepotMulticomponentReactionsAbstractMultieomponentreactions(MCRs)havea

2、ttractedincreasingattentionbyvirtueoftheirconvergence，productivityeaseofexecutionandgenerallyhi曲yieldsofproductsAsaresult，ithasbecomeapowerfultoolforgeneratinglibrariesofmoleculesforthediscoveryandstructuraloptimizationo

3、fbiologicallyactiveleadsandpotentialdrugcandidatesInaddition，indolederivativeshavelongbeenthefocusofconsiderableattentionduetotheirabundantexistenceinnumerousnatureproducts弱wellastheirextensiveapplicationsinbiologicaland

4、pharmacologicalareaInthisdissertation，OUtattentionmainlyfocusesontheconstructionofindole—containgheterocyclicskeletonsviaonepotmulticomponentreactionsPartI：Anewseriesofindolecontainingp)，ridinederivativesrepresentedby6(1

5、Hindol一3一y1)4aryl2，2’bipyfidine5一carbonitrilesweresynthesizedv／aone—potmulticomponentreactionsof3cyanoacetylindoles，aldehydes，heterocyclicketonesandammoniumacetateParticularlyvaluablefeaturesofthismethodincludehighyields

6、ofproducts，broadsubstratesscopeandstraightforwardprocedurePartII：Aregioseletivesynthesistoanewseriesofindolecontainingdihydropyrido[2，3一d]Pyrimidinederivativesviatheonepotmulticomponentcyclocondensationof3cyanoacetylindo

7、les，aldehydes，and6aminopyrimidine2，4(1H3H)dionehasbeendisclosed，itisnoteworthytopointoutthatthereactionproceedssmoothlyinachemoandregioselectivewayandgivestheanticipatedproductsingoodyieldswithouttheformationofanyotheris

8、omersPartIII：Afacileandefficiententryintohighlyfunctionalized3spiropyrrolidineoxindoles，3spiropyrrolizidineoxindoles，and3spiropyrrolidineacenaphthenonesviaone—potfourcomponent[32】cycloadditionof3cyanoacetylindoles，aldehy