不同來源的外泌體對(duì)特發(fā)性肺纖維化的免疫調(diào)節(jié)作用

1、不同來源的外泌體對(duì)特發(fā)性肺纖維化的免疫 調(diào)節(jié)作用吳佳敏張煒張興陳麒【摘要】特發(fā)性肺纖維化(IPF)是一種慢性進(jìn)行性的間質(zhì)性肺病， 其發(fā)病機(jī)制目前尚無定論。成纖維細(xì)胞直接參與IPF過程的理論已被 廣泛接受，同時(shí)研究認(rèn)為IPF的形成、開展與炎癥、免疫息息相關(guān)， 主要表現(xiàn)為免疫細(xì)胞與成纖維細(xì)胞間的相互作用。外泌體是細(xì)胞間進(jìn) 行生物信息通信的重要載體，不同細(xì)胞來源的外泌體攜帶著不同的信 號(hào)因子，可作為免疫細(xì)胞與成纖維細(xì)胞的橋梁，在IPF的炎癥

2、反響和 免疫調(diào)節(jié)中發(fā)揮作用，同時(shí)外泌體或?qū)⒊蔀榕R床診斷和治療IPF的重 要方法。該文就不同細(xì)胞來源的外泌體在IPF中的研究進(jìn)展進(jìn)行綜述, 以了解外泌體作為細(xì)胞間信息交流的載體在調(diào)節(jié)IPF的形成與開展 中的作用?！娟P(guān)鍵詞】特發(fā)性肺纖維化；外泌體；炎癥；免疫；成纖維細(xì)胞；間質(zhì)性 肺炎【 Abstract ] Idiopathicpulmonaryfibrosis ( IPF ) isachronicprogressiveinte

3、rstitiallungdisease. Thepathogenesi sofIPFremainselusive. Thetheorythatfibroblastsdirectlypartic ipateinthelPFprocesshasbeenwidelyaccepted. Moreover,studieshavedemonstratedthattheincidenceanddevelopmentofIPFi sintimate

4、lyrelatedtoinflammatoryandimmunity,whichismainlymanifestedwiththeinteractionbetweenimmunecens andfibroblasts. Exosomesareimportantcarriersforbiological inf ormationcommunicationbetweencelIsIPFBALcells. Oncotarget, 2022,

5、7 (46)： 74569-74581.myofibroblasttransitioninthehumanlung. Biochem BiophysResCommun, 2022, 528 (2)： 269-275.[31]ProebstlD , VoisinMB , WoodfinA , etal. Pericytessupportneutrophi1subendothelialcellcrawlingan dbreach

6、ingofvenularwallsinvivo. JExpMed , 2022 , 209 ( 6 )： 1219-1234.[32]NavarroR , CompteM , A Ivarez-VallinaL , etal. Immuneregulationbypericytes：modulatinginnateandadaptiveimmunity. Frontlmmunol, 2022, 7： 480.[33]Xie

7、H ,GaoYM ,ZhangYC ,etal. Lowlet-7dexosomesfrompulmonaryvascularendothelialcells drivelungpericytefibrosisthroughtheTGF B RI/FoxMl/Smad/B -ca teninpathway. JCellMolMed, 2022, 24 (23)： 13913-13926.[34]DinhPUC , Pa

8、udelD , BrochuH , etal. InhalationoflungspheroideelIsecretomeandexosomespromot eslungrepairinpulmonaryfibrosis. NatCommun, 2022, 11 (1)： 1064. (收稿日期：2022-09-07) (本文編輯：林燕薇)andexosomesfromdifferentce11sourcescancarryd

9、ifferentsignaif actors, whichserveabridgebetweenimmunecellsandfibroblasts, andplayaroleintheinflammatoryresponseandimmuneregulationofl PF. Therefore,exosomesmaybecomeavitalpatternforclinicaldiagnosisandtreatm entofIPF.