胰島素治療與優(yōu)降糖治療對(duì)新診斷的2型糖尿病患者β細(xì)胞功能及代謝控制的研究

1、山西醫(yī)科大學(xué)碩士學(xué)位論文胰島素治療與優(yōu)降糖治療對(duì)新診斷的2型糖尿病患者β細(xì)胞功能及代謝控制的研究姓名：郭志芹申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：內(nèi)分泌科學(xué)指導(dǎo)教師：楊靜20070506山一醫(yī)科大學(xué)問等頤f學(xué)位論文StudyofEffectofInsulinVersusGlibenclamideonIBceliFunctionAndMetabolicControlinRecentlyDiagnosedType2DiabetesPatientsABST

2、RACTObjective：StudytheeffectofearlyinsulintreatmentandoralGlibenclamideonglycemiccontrolandpancreaticB—cellfunctioninrecentlydiagnosedtype2diabetesmellitusMethods：Fortysixpatientsrecentlydiagnosedastype2diabetesmellitusw

3、ithfastingplasmaglucose(FPG)of$12mmol／Landglycosylatedhemoglobin(HbAIc)2_8O％wererandomlydividedintothreegroups：groupCSII，groupMDIandglibenclamidetreatedgroupThepatientswerefirsttreatedandthenwaitedfortheirglycemiaforeach

4、patientwassteadyinacertainrangeThenglycemiccontrol，bodymassindex(BMl)，themeanareaunderthecurveofinsulin(AUC)，HOMA—BcalculatedfromthesteadystatemodelandHOMAIRofthreegroupswereanalyzedandcomparedbetween3groupsatthetimewhen

5、glycemiawassteadyandatthetimeforthefollowupaftersixmonth。Measurementdatawereexpressedwithmean4standarddeviation；thecomparisonofindexesbetweenthreegroupswasanalyzedusingsinglefactoranalysisofvariance，andthecomparisonofind

6、exesineachgroupWasanalyzedusingmulti—factoranalysisofvarianceAllstatisticalanalyseswerecalculatedwithsoftwareSPSSll5andstatisticalsignificanceWasestablishedwhenP005Results：ComparingFPGofgroupCSllwiththatofgroupMDI，itWasn

7、otstatisticallysignificant；howevehFPGofglibenclamidegroupWassignificantlyincreasedcomparingwiththoseofgroupsCSIIandMDIafterstandardbloodglUCOSCcontrolandfollowupofsixmonthslater(尸o05)Followingtreatmentandfollowupofsixmon

8、thslaterBMIofthreegroupswereallsignificantlyincreased，respectivelycomparingwithBMIbeforetherapy(Po05)ThereWasnostatisticalsignificanceinBMIofthreegroupsbetweenstandardbloodglucosecontrolandfollow—upofsixmonthslaterFollow

9、ingtreatmentandfollowupofsixmonthslaterHOMA一6andAUCofthreegroupswereallsignificantlyincreasedcomparingwiththatbeforetherapyrespectively(Po01)ThereWasnostatisticallysignificanceinHOMA—BandAUCofgroupCSIIandgroupMDIbetweens

10、tandardbloodglucosecontrolandfollowupofsixmonthslaterComparingwithgroupCSIIandgroupMDI，HOMA一13andAUCofglibenclamidetreatedgroupwereallsignificantlydecreasedfollowingtreatment(P0。05)，andtheyweresignificantlyincreasedcompa