大環(huán)內(nèi)脂類(lèi)耐藥性對(duì)空腸彎曲桿菌毒力和適應(yīng)性的影響.pdf

1、分類(lèi)號(hào)華中農(nóng)業(yè)大學(xué)博士學(xué)位論文大環(huán)內(nèi)醋類(lèi)耐藥性對(duì)空腸彎曲桿菌毒力和適應(yīng)性的影響ImPactofMaerolideResistanceontheViruleneePr0PertiesandFitnessinCan耳)J，tobacterjejuni研究生:vassirAliA一moftiAhmed指導(dǎo)教師:袁宗輝教授指導(dǎo)小組:戴夢(mèng)紅副教授郝海紅講師專(zhuān)業(yè):基礎(chǔ)獸醫(yī)學(xué)獲得學(xué)位名稱(chēng):農(nóng)學(xué)博士研究方向:生物化學(xué)與分子生物學(xué)獲得學(xué)位時(shí)間:2011年

2、6月華中農(nóng)業(yè)大學(xué)動(dòng)物醫(yī)學(xué)院二O一一年六月2.2.8Illustrativecaleulationsofseleetionrateeonstant(R)，MalthusianParameter(M)，numberofthedoubling(D)relativefitness(W)ofeachcompetit...................................................................

3、.................................……232.2.9Heatshocktoleranceassay.................................................................……242.2.10C01onizationofbalbcmice.........................................................

4、.....……252.2.11Statisticalanalysis............................................................................……262.3Resuhs.................................................................................................

5、..........……262.3.1Deter們ninationofm以ationsinmaero【ideresistantm以ants...............……262.3.2Determinationofminimali雨bityconeentration(MIC)................……282.3.3Growthrateofsl221straineomParedtoSTY，SEandSTIstrains..……

6、292.3.4Relativefitnessofsl22lstraineomParedtoSTY，SEandSTIstrains.…302.3.5Heatshocktoleranceassay.................................................................……322.3.6Colonizatlonofbalbcmicem0del......................

7、...............................……332.4Oiscussion......................................................................................................……353.ImPaetoferythromyeinresistaneeontheViruleneeProPertiesandfitness

8、ofCa刀聊夕lobacterjej’uni..................................................................................................……383.1Introduction......……‘........................................................................

9、.............……383.2Materialsandmethods.......................................................……，.....................……403.2.1Bacteria1strainandcu1turec0nditi0ns...............................................……403.2.2In

10、vitroinduction................................................................................……403.2.3AntimicrobialsuscePtibilitytesting....................................................……403.2.4Cjej’unjgenomieDNAextr

11、actiondeterminationofmutationsinmacrolideactionsites.....................................................……，......................……403.2.5Resistaneetobilesalts(sodiumdeoxycholate).……，..........................……413.2.6I